A Synthetic Organic Chemist with eight years of hands-on research experience in academia and industry in diversified areas and roles. Superior background on multi-disciplinary projects. Highly experienced in chemical kinetics and reaction mechanisms.
CAREER HIGHLIGHTS
As a post-doctoral fellow, my contributions to different projects resulted in two publications in the year of 2009 (Journal of Combinatorial Chemistry), 2010 (Journal of Medicinal Chemistry), and the submission of 55 original compounds (10 mg each, purity over 95%) to the National Institute of Health (NIH) in the search for lead candidates against diseases. During graduate school, I have examined the thermal effect on enhancement of β-selectivity of glycosylation reactions (Tetrahedron Letters 2005). Increased collaborative research investigations among new graduate students as a result of my investigation to the mechanism involved in the glycosylation reaction of mannosyl iodides (The Journal of Organic Chemistry, 2007).
SUMMARY OF QUALIFICATIONS
Eight years of experience in research-intensive implementations; mainly in the fields of carbohydrate chemistry, heterocyclic chemistry, small-molecule synthesis, solid-phase peptide synthesis, synthesis of glycolipids, and mechanism evaluation. Thorough understanding of organic synthesis. Ability to design and diverse efficient syntheses of target molecules and to interpret experimental outcomes. Strong background on multi-disciplinary projects (total synthesis, small-molecule heterocyclic chemistry, carbohydrate chemistry, solid-phase peptide synthesis, and self-assembly). Maintain records of capability to design, execute, and characterize complex organic sequences, utilizing Nuclear Magnetic Resonance (NMR), Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), and HPLC techniques. Design and synthesis of small-molecules, directed towards biologically relevant targets. Outstanding supervision, motivation, and evaluation of scientists. Self-directed in accomplishing tasks with attention to details to ensure goals are met.
EDUCATION
Ph.D. in Chemistry
UNIVERSITY OF CALIFORNIA Davis, CA
Dissertation: Synthetic and Physical Organic Studies of Stereoselective Glycosylation Reactions Using Glycosyl Iodides.
Bachelor of Science: Chemistry
UNIVERSITY OF ALAZHAR
Cairo, EGYPT
PROFESSIONAL EXPERIENCE
Centre National de la Recherche Scientifique (CNRS), Institute of Charles Sadron (ICS), Strasbourg, France (2/2010 - 4/2001)
Post-Doctoral Fellow
Performed research on Supramolecular chemistry and self -assemblies.
Research involved design and synthesis of a system that is capable of transmitting data from one end of the molecule, upon binding to a receptor, to the other end, instigating a reaction. Synthesis of symmetrical and unsymmetrical glycopeptides to study specific binding of lectins to Alpha-linked mannose. Diversification of a triarylamine system by incorporating mannosyl moieties, and investigation of the new system for self-assembly.
University of California , Davis, CA (9/2002 - 12/2009)
Post-Doctoral Fellow
Employed one-bead-one-compound (OBOC) combinatorial peptide libraries for development of effective strategies for diagnosis of prostate cancer.
Interacting with a multidisciplinary team of medical doctors, biologists, medicinal chemists, and external collaborators. Proposed and achieved synthetic schemes for the construction of peptide libraries utilizing solid phase synthesis. Implemented the concept of one-bead-one-compound in peptide synthesis in order to prompt the discovery of lead compounds for drug discovery.
Post-Doctoral Fellow
Developed, implemented and maintained a complete research framework for the synthesis of small molecule heterocyclic library that assists in targeting new drug discovery.
Analyzed and produced an allyl analog of SF-03, a potentiator of defective ∆F508-Cystic Fibrosis transmembrane conductance regulator chloride channel gating. Efficiently Synthesized a new class of bis-heterocycles, Thia/Oxa-diazolothiazoles, that are tested as potential Correctors of defective ∆F508-Cystic fibrosis. Developed and completed a detailed study on the synthesis of thiazoloisoxazoles. Designed and synthesized target molecules that individually inhibits multiple chorismate-utilizing enzymes.
Graduate Laboratory Fellow
Performed studies and enhancements on the b-stereoselectivity of glycosylation reactions through the utilization of inverse thermal study.
Delivered enhancements to Beta-stereoselectivity of glycosylation reactions. Performed mechanistic studies on the stereoselective synthesis of Beta-mannosides from mannosyl iodide using Alpha-deuterium kinetic isotope effects. Generated and utilized reactions for 4,6-O-benzylidine-D-mannosyl iodide with trimethylene oxide, to produce Beta-mannoside in a 100% diastereoselectivity. Employed trimethylene oxide (TMO) in galactosidation reactions of reactive nucleophiles to investigate TMO reactivity as a competitive nucleophile.
Teaching Assistant in Organic Chemistry
Involved in training undergraduate students by proctoring and teaching laboratory objectives; improving quality results and achieving course objectives.
Provided a stimulating learning environment in which students developed their full potential. Helped to prepare students for the future workforce by introducing new laboratory techniques and encouraging interactive group-work and problem solving. Proven ability to stand in front of groups of undergraduate students and present class materials and tutorials. Employed a broad range of instructional techniques to retain student interest and maximize individual learning within a group environment. Supervised recitation sessions to further educational knowledge. Related effectively to students of diverse cultural backgrounds and tailored teaching methods to suit individual needs. Trained undergraduate students on the proper utilization of a research laboratory, along with the efficient use of instruments, data documentation, and group work presentations.
Involved in serving organization by planning and implementing operational and staff objectives; planning and maintaining efficient data driven operations; improving textile quality results and achieving financial objectives.
Accomplished human resource objectives by recruiting, selecting, coaching, and training employees. Communicated job expectations by planning, monitoring, appraising, and reviewing job contributions. Supervised an elite team that assisted with the research studies involving new physical properties of textiles via modifications in chemical properties such as the pH, viscosity, and treating fibers with dyes of proper functionalities.
PUBLICATIONS
Ziebart, K. T.; Dixon, S.; Avila, B.; El-Badri, M. H.; Guggenheim, K.; Kurth, M. J.; Toney, M. D.: “Targeting Multiple Chorismate-utilizing Enzymes with a Single Inhibitor: Validation of a Three-stage Design” J. Med. Chem. 2010, 53 (9), 3718–3729. El-Badri, M. H.; Kurth, M. J.: “Synthesis of Thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles” J. Comb. Chem.2009, 11, 228-238. El-Badri, M. H.; Kurth, M. J.: “Synthesis and evaluations of Thiadiazolo- and Oxadiazolothiazoles as Correctors of defective ∆F508-Cystic fibrosis” Manuscript in preparation. El-Badri, M. H.; Willenbring, D.; Tantillo, D. J.; Gervay-Hague, J.: “Mechanistic studies on the Stereoselective Formation of Beta-Mannosides from Mannosyl Iodides Using Alpha-Deuterium Kinetic Isotope Effects” J. Org. Chem. 2007, 72, 4663-4672. El-Badri, M. H.; Gervay-Hague, J.: “Thermal Effect in Beta-Selective Glycosylation Reactions Using Glycosyl Iodides” Tetrahedron Lett. 2005, 46, 6727-6728. El-Badri, M. H.; Gervay-Hague, J.: “Unique Reactivity of Trimethylene Oxide in Glycosylation Reactions with Galactosyl Iodide” Manuscript in preparation. El-Badri, M. H.; Moulin, E.; Giuseepone, N.: “Synthesis of Hiarchaeal Mannolipids and Evaluation of their Binding to Concanavalin-A” Manuscript in preparation. El-Badri, M. H.; Giuseepone, N.: “Synthesis and Self-Assembly of Mannose-functionalized Triarylamines” Manuscript in preparation.
PROFESSIONAL PRESENTATIONS
Mechanism and Stereoselective Synthesis of Beta-mannosides Using Mannosyl Iodide, Oral presentation, ACS National Meeting, Atlanta, March 2006. Unique Reactivity of Trimethylene Oxide in Glycosylation Reactions with Galactosyl Iodide, Poster, Ninth Annual Symposium of Glycobiology, San Diego, Jan. 2006. Thermal Effect in Beta-Selective Glycosylation Reactions Using Glycosyl Iodides, Poster,ACS Regional Meeting, Sacramento, CA, Oct. 2004. Thermal Effect in Beta-Selective Glycosylation Reactions Using Glycosyl Iodides, Poster,Gordon Conference, Tilton, NH, June 2003.
AFFILIATIONS & AWARDS
American Chemical Society Member
Reviewer of the Journal of Organic Chemistry and Organic Letter – January 2006 to Present
OTHER QUALIFICATIONS
Laboratory: Complex organic synthesis (in both fields of solution and solid phase chemistry), Column chromatography, Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared spectroscopy (FTIRs), High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LCMS), Gas Chromatography (GC), Thin Layer Chromatography (TLC), Dynamic Light Scattering (DLS), Tip-Sonication and Extrusion techniques for preparing lipid vesicles, and preparation of supported membrane bi-layers, and QCM. Computer: MS Office, Windows 98/2000/NT/XP/Vista, Chemdraw, Scifinder. Languages: English (Fluent), Arabic (Fluent), French (Beginner).
As a post-doctoral fellow, my contributions to different projects resulted in two publications in the year of 2009 (Journal of Combinatorial Chemistry), 2010 (Journal of Medicinal Chemistry), and the submission of 55 original compounds (10 mg each, purity over 95%) to the National Institute of Health (NIH) in the search for lead candidates against diseases.
Research involved design and synthesis of a system that is capable of transmitting data from one end of the molecule, upon binding to a receptor, to the other end, instigating a reaction.